Effect of salt hydrate pair on lipase-catalyzed regioselective monoacylation of sucrose

✍ Scribed by Jae Eun Kim; Jeong Jun Han; Jung Hae Yoon; Joon Shick Rhee

• Book ID: 101243188
• Publisher: John Wiley and Sons
• Year: 1998
• Tongue: English
• Weight: 71 KB
• Volume: 57
• Category: Article
• ISSN: 0006-3592
• DOI: 10.1002/(sici)1097-0290(19980105)57:1<121::aid-bit15>3.0.co;2-n

✦ Synopsis

Sucrose monoesters of a fatty acid were synthesized by using lipase in a solvent-free system. When lipase from Mucor miehei was used as a catalyst with capric acid as the donor and sugar as the acceptor, sucrose 6-monocaprate was predominantly produced in a yield of 25.3%. The yield of product was significantly increased by the direct addition of a suitable pair of solid salt hydrates to the reaction mixture to control the water activity (a w ). Among the salt hydrate pairs investigated, the barium hydroxide, 8/1H 2 O pair resulted in the highest yield of the product. This salt addition method was also successfully employed for acylation of primary hydroxyl groups in various unprotected mono-and disaccharides such as glucose, galactose, fructose, trehalose, mannose, maltose, and lactose.