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Effect of roscovitine, a selective cyclin B-dependent kinase 1 inhibitor, on assembly of the nucleolus in mitosis

โœ Scribed by O. O. Zharskaya; A. S. Barsukova; O. V. Zatsepina

Book ID
110154968
Publisher
Springer
Year
2008
Tongue
English
Weight
734 KB
Volume
73
Category
Article
ISSN
0006-2979

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## Abstract Inhibitors of cyclinโ€dependent kinases (CDKs) undergoing clinical trials as anticancer agents usually target several CDKs in cells. Some of them are also able to increase cellular levels of p53 protein and to activate p53โ€regulated transcription. To define the role of p53 in the antican