Covalent attachment of poly(ethylene glycol) (PEG) to therapeutic antibody fragments has been found effective in prolonging the half-life of the protein molecule in vivo. In this study analytical ultracentrifugation (AUC) in combination with small angle X-ray scattering (SAXS) has been applied to a
Effect of rigid fragments on the conformation of crown-ethers
β Scribed by L. P. Trigub; V. E. Kuz'min
- Publisher
- SP MAIK Nauka/Interperiodica
- Year
- 1990
- Tongue
- English
- Weight
- 263 KB
- Volume
- 31
- Category
- Article
- ISSN
- 0022-4766
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The 'H and "C NMR spectra of a series of structurally related crown ethers were recorded, and alkali metal complexation of the crown ethers was studied for different Li, Na and K salts. The alkali metal salt-induced 'H and "C chemical shifts are discussed in terms of conformational changes within th