Effect of rifampicin on the pharmacokinetics of itraconazole in normal volunteers and AIDS patients
β Scribed by S. Jaruratanasirikul; S. Sriwiriyajan
- Publisher
- Springer
- Year
- 1998
- Tongue
- English
- Weight
- 262 KB
- Volume
- 54
- Category
- Article
- ISSN
- 0031-6970
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## Abstract Ten healthy volunteers were given βRifaprimβ in the dosage recommended for the treatment of urinary infections in man (rifampicin 300 mg + trimethoprim80 mg in the morning and double these amounts at night, for 7 days). Levels of both drugs in the serum and urine were determined on the
Tuberculosis chemotherapy involves combination of the drugs isoniazid (INH), rifampicin (RMP) and pyrazinamide (PYR) for a 6-month period. The present work investigated the influence of RMP and PYR on the pharmacokinetic parameters of INH when groups of rats were pre-treated for 21 days with INH alo