Junin virus infection in guinea pigs is known to be similar to human Argentine hemorrhagic fever (AHF). The guinea pig was chosen as a model for transplacental transmission of Junin virus, as both guinea pig and man have a similar placental structure. Pregnant guinea pigs were infected with the path
Effect of Ribavirin on Junin Virus Infection in Guinea Pigs
β Scribed by M. Salazar; N. E. Yun; A. L. Poussard; J. N. Smith; J. K. Smith; O. A. Kolokoltsova; M. J. Patterson; J. Linde; S. Paessler
- Book ID
- 114942478
- Publisher
- Wiley (Blackwell Publishing)
- Year
- 2012
- Tongue
- English
- Weight
- 283 KB
- Volume
- 59
- Category
- Article
- ISSN
- 1863-1959
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
Administration of cyclophosphamide (CY) to guinea pigs infected with a lethal strain of Junin virus (JV) delayed the time of death, with survival of a small number of animals. Virological studies showed a temporary decrease of virus concentration in blood and viscera shortly after the CY injection.
In order to assess the effect of the antiviral Ribavirin on the course of JunΓn virus infection in Callithrix jacchus, seven inoculated monkeys were treated with 15 mg of the drug, twice a day, starting 6 days after infection when all animals were viremic. The three untreated controls showed typical
The purpose of this work was to elucidate the pathogenesis of attenuated Junin virus (JV) strains in the guinea pig model. Three groups of guinea pigs were infected by the IM route with lo3 PFU of the XJC13 and XJO-attenuated strains or with the XJ pathogenic strain of JV, respectively. Viremia was
Guinea pigs infected with Argentine hemorrhagic fever virus (Junin) were treated with pooled, homologous convalescent sera. Use of 15,000 or 5,000 therapeutic units of immune sera prevented all signs of illness when administered within 24 hr of infection. We could also prevent illness and death in i