Effect of repeated laser microsurgical operations on laryngeal cancer prognosis

✍ Scribed by Alexander D. Karatzanis; Frank Waldfahrer; Georgios Psychogios; Joachim Hornung; Johannes Zenk; George A. Velegrakis; Heinrich Iro

• Publisher: John Wiley and Sons
• Year: 2009
• Tongue: English
• Weight: 402 KB
• Volume: 32
• Category: Article
• ISSN: 1043-3074
• DOI: 10.1002/hed.21272

✦ Synopsis

Abstract

Background

The aim of this study was to evaluate whether repeated sessions of transoral CO~2~ laser microsurgery (TLM) aiming to achieve clear histologic margins carry a negative effect on the prognosis of laryngeal cancer.

Methods

This was a retrospective evaluation of 763 cases that underwent primary TLM treatment for laryngeal cancer. Cases were compared for overall survival and local control rates with respect to status of surgical margins and number of procedures necessary to achieve these margins.

Results

No significant differences were noted among cases with negative surgical margins regardless of the number of procedures necessary to achieve these margins. On the other hand, positive margins at the end of surgical treatment carried significant negative prognostic effect.

Conclusion

The prognostic effect of negative surgical margins in TLM for laryngeal cancer is significant regardless of the number of procedures required to obtain such margins. © 2009 Wiley Periodicals, Inc. Head Neck, 2010