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Effect of renal dysfunction in dogs on the disposition and marrow toxicity of melphalan

โœ Scribed by Alberts, D S; Chen, H G; Benz, D; Mason, N L

Book ID
118675395
Publisher
Nature Publishing Group
Year
1981
Tongue
English
Weight
641 KB
Volume
43
Category
Article
ISSN
0007-0920

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THE EFFECT OF EXPERIMENTAL RENAL FAILURE
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The pharmacokinetic disposition of tolfenamic acid, an NSAID, after a single administration of tolfenamic acid (4 mg kg 71 ) by the intravenous (IV) route was compared in eight dogs before and after a surgically induced renal failure. Renal impairment was conยฎrmed by a signiยฎcant increase ( p50ยด001)