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Effect of regulatory T cells and adherent cells on the expansion of HBcAg-specific CD8+ T cells in patients with chronic hepatitis B virus infection

✍ Scribed by Xuefen Li; Yu Chen; Zhaowen Ma; Bo Ye; Wei Wu; Lanjuan Li

Book ID: 113527294
Publisher: Elsevier Science
Year: 2010
Tongue: English
Weight: 703 KB
Volume: 264
Category: Article
ISSN: 0008-8749
DOI: 10.1016/j.cellimm.2010.04.009

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Chronic hepatitis B virus (HBV) infection is characterized by a weak immune response to HBV. Regulatory T cells (T(reg)) can suppress the function of effector T cells and may thus be key players in this impaired immune response. Changes in the functionality or number of T(reg) could explain the decr