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Effect of pyrazinamide on rifampicin kinetics in patients with tuberculosis

โœ Scribed by Jain, A.; Mehta, V.L.; Kulshrestha, S.

Book ID
122788264
Publisher
Elsevier Science
Year
1993
Tongue
English
Weight
500 KB
Volume
74
Category
Article
ISSN
0962-8479

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Tuberculosis chemotherapy involves combination of the drugs isoniazid (INH), rifampicin (RMP) and pyrazinamide (PYR) for a 6-month period. The present work investigated the influence of RMP and PYR on the pharmacokinetic parameters of INH when groups of rats were pre-treated for 21 days with INH alo