Effect of protopanaxadiol derivatives in high glucose-induced fibronectin expression in primary cultured rat mesangial cells: Role of mitogen-activated protein kinases and Akt

Different inhibitory effect of imatinib

Different inhibitory effect of imatinib on phosphorylation of mitogen-activated protein kinase and Akt and on proliferation in cells expressing different types of mutant platelet-derived growth factor receptor-α

✍ Akiko Ohashi; Kazuo Kinoshita; Koji Isozaki; Toshirou Nishida; Yasuhisa Shinomur 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 French ⚖ 195 KB 👁 1 views

## Abstract Most gastrointestinal stromal tumors (GISTs) have gain‐of‐function mutations of the c‐__kit__ gene. Previously, we found 2 types of gain‐of‐function mutation of the __PDGFRA__ gene, Val^561^ to Asp and Asp^842^ to Val, in about half of GISTs without c‐__kit__ gene mutations. Although th