The effects of prostaglandin E 2 (PGE 2 ) on the proliferation and differentiation of osteoblastic cells were studied in osteoblast-like cells isolated from adult rat calvaria. Treatment of the cells with PGE 2 within the concentration range 10 ฯช8 -10 ฯช5 M resulted in a dose-dependent increase in al
Effect of prostaglandin E2on mineralization of bone nodules formed by fetal rat calvarial cells
โ Scribed by T. Nagata; K. Kaho; S. Nishikawa; H. Shinohara; Y. Wakano; H. Ishida
- Publisher
- Springer
- Year
- 1994
- Tongue
- English
- Weight
- 848 KB
- Volume
- 55
- Category
- Article
- ISSN
- 1432-0827
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The effects of prostaglandin E 2 (PGE 2 ) on the parameters for proliferation and differentiation were studied in calvarial osteoblast-like cells isolated from rats of various ages. In cells not treated with PGE 2 , it was found that mineralized bone nodule (BN) formation, alkaline phosphatase (ALP)
## Abstract Loading frequency is an important parameter for the stimulation of bone formation in vivo. It is still unclear how the information of external loading characteristics is conveyed to osteoblasts and osteoclasts. Osteocytes are thought to detect mechanical loads by sensing fluid flow thro
We investigated the effects of vitamin D3 on the signaling pathways by prostaglandin E, (PGE2) in osteoblast-like MC3T3-El cells. The pretreatment with 1,25-dihydroxyvitamin D3 (1 ,25-(OH),D3), an active form of vitamin D3, significantly inhibited cAMP accumulation induced by 10 (LM PGE, in a dose-d