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Effect of propentofylline on cerebral metabolism of rats

✍ Scribed by V. Stefanovich

Publisher: John Wiley and Sons
Year: 1985
Tongue: English
Weight: 616 KB
Volume: 6
Category: Article
ISSN: 0272-4391
DOI: 10.1002/ddr.430060405

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✦ Synopsis

Propentofylline (HWA 285) [3-methyl-l-(5'-oxohexyl)-7-propylxanthine] is in in vitro experiments a good inhibitor of cAMP and cGMP phosphodiesterases in the rat brain and cerebral microvessels. In in vivo experiments it modulates cAMP and cGMP systems and GABA concentration in four examined structures of rats: cortex, hypothalamus, cerebellum, and striatum. Propentofylline (5 mg/kg i.v.) doesn't influence levels of cerebral energy reserves in normal rats but prevents to a significant degree some of the changes in metabolite levels caused by anoxia (30 s of nitrogen breathing). This antianoxic effect occurs at 5 min and disappears 20 min after administration of the drug. Caffeine (5 mg/kg i.v.) shows a trend toward further aggravation of anoxia. The modulating effect of propentofylline on cAMP and cGMP systems, GABA levels, and especially cerebral energy metabolism in anoxia is possibly related to the potential therapeutic effect of this drug.

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