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Effect of prolactin on DNA methylation in the liver and kidney of rat

✍ Scribed by P. M. S. Reddy; P. R. K. Reddy

Publisher
Springer
Year
1990
Tongue
English
Weight
328 KB
Volume
95
Category
Article
ISSN
0300-8177

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✦ Synopsis

Prolactin is an important growth modulatory hormone in fetal and adult tissues. It stimulates DNA synthesis and enzymatic markers of the G1 phase of cell cycle in rat liver and other tissues. In this study the effects of prolactin on 5-methyl cytosine content in liver and kidney of rats was studied using HPLC. Prolactin treatment caused hypomethylation of DNA in the liver and kidney of immature rats at 48 h after treatment and the effect remained even at 72 h. Prolactin also caused hypomethylation of DNA in the kidney and liver of adult rats at 48 h after treatment. These results indicate that prolactin probably regulates DNA methylation in the liver and kidney of immature and adult rats.

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