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Effect of Processing Variables on the Morphology of Electrospun Poly[(lactic acid)-co-(glycolic acid)] Nanofibers

✍ Scribed by Fujuan Liu; Rui Guo; Mingwu Shen; Shanyuan Wang; Xiangyang Shi

Publisher
John Wiley and Sons
Year
2009
Tongue
English
Weight
935 KB
Volume
294
Category
Article
ISSN
1438-7492

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✦ Synopsis

Abstract

A systematic study of the effects of $\overline M _{\rm w}$, flow rate, voltage, and composition on the morphology of electrospun PLGA nanofibers is reported. It is shown that changes of voltage and flow rate do not appreciably affect the morphology. However, the $\overline M _{\rm w}$ of PLGA predominantly determines the formation of bead structures. Uniform electrospun PLGA nanofibers with controllable diameters can be formed through optimization. Further, multi‐walled carbon nanotubes can be incorporated into the PLGA nanofibers, significantly enhancing their tensile strength and elasticity without compromising the uniform morphology. The variable size, porosity, and composition of the nanofibers are essential for their applications in regenerative medicine.

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