✦ LIBER ✦

Effect of process change from perfusion to fed-batch on product comparability for biosimilar monoclonal antibody

✍ Scribed by Soo-Young Lee; Young-Bum Kwon; Jong-Moon Cho; Keun-Hee Park; Shin-Jae Chang; Dong-Il Kim

Book ID: 116845680
Publisher: Elsevier Science
Year: 2012
Tongue: English
Weight: 543 KB
Volume: 47
Category: Article
ISSN: 1873-3298
DOI: 10.1016/j.procbio.2012.05.017

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

Fed-batch bioreactor process scale-up fr

Fed-batch bioreactor process scale-up from 3-L to 2,500-L scale for monoclonal antibody production from cell culture

✍ Jeng-Dar Yang; Canghai Lu; Brad Stasny; Joseph Henley; Woodrow Guinto; Carlos Go 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 381 KB 👁 2 views

## Abstract This case study focuses on the scale‐up of a Sp2/0 mouse myeloma cell line based fed‐batch bioreactor process, from the initial 3‐L bench scale to the 2,500‐L scale. A stepwise scale‐up strategy that involved several intermediate steps in increasing the bioreactor volume was adopted to

A systematic approach to the validation

A systematic approach to the validation of process control parameters for monoclonal antibody production in fed-batch culture of a murine myeloma

✍ Enda B. Moran; Steve T. McGowan; John M. McGuire; Janet E. Frankland; Israel A. 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 English ⚖ 325 KB 👁 2 views