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Effect of pre-stroke use of ACE inhibitors on ischemic stroke severity

✍ Scribed by Magdy Selim; Sean Savitz; Italo Linfante; Louis Caplan; Gottfried Schlaug

Book ID
115009391
Publisher
BioMed Central
Year
2005
Tongue
English
Weight
256 KB
Volume
5
Category
Article
ISSN
1471-2377

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## Abstract Poly(ADP‐ribose) polymerase (PARP)‐1 plays an important role in the pathogenic mechanism of ischemic stroke. A number of studies have been undertaken to develop PARP‐1 inhibitors for clinical use. We report on the newly developed PARP‐1 inhibitors, among which **12a** showed good activi