The use of a fluorescent methotrexate pr
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David G. Poppitt; Alan T. McGown; Brian W. Fox
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Article
📅
1984
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Springer
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English
⚖ 374 KB
## Cells res&tant to methotrexate (LI210/R7A) and possessing an increased level of dihydrofolate reductase due to gene amplification can be detected by the technique of flow cytofluorimetry using a new fluorescent derivative of methotrexate (F-MTX) based on a putrescine linker. Comparative studies o