## Abstract The influence of dose volume on drug absorption following oral administration of a highly and a poorly water soluble drug was examined in male SpragueβDawley rats. A constant mass of each ^14^Cβlabeled compound was given via gavage in dose volumes of 1, 5, 10, and 20 mL kg^β1^. Blood le
Effect of polysorbates on absorption rates of water-soluble, micelle-free drugs administered intramuscularly in the rat
β Scribed by Hiroshi Kobayashi; Taeko Nishimura; Katsuhiko Okumura; Shozo Muranishi; Hitoshi Sezaki
- Publisher
- John Wiley and Sons
- Year
- 1974
- Tongue
- English
- Weight
- 508 KB
- Volume
- 63
- Category
- Article
- ISSN
- 0022-3549
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π SIMILAR VOLUMES
Subcutaneous drug absorption rates from aqueous suspensions were measured in the mouse and the rabbit by a local clearance method and compared with those in the rat. A plot of the cube root of the residual fraction (W/Wo) of the drug a t the injection site uersus time ( t ) gave a good linear relati
The aim of the present work was to establish appropriate conditions for the dissolution/permeation system (D/P system) to estimate the effect of food intake on oral drug absorption. The D/P system is an in vitro assay system to evaluate the drug dissolution and permeation processes after oral admini