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Effect of polyethlene glycol 400 on the penetration of drugs through human cadaver skin in vitro

✍ Scribed by Pramod P. Sarpotdar; James L. Gaskill; Robert P. Giannini

Publisher: John Wiley and Sons
Year: 1986
Tongue: English
Weight: 299 KB
Volume: 75
Category: Article
ISSN: 0022-3549
DOI: 10.1002/jps.2600750107

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✦ Synopsis

The effect of polyethylene glycol 400 on the penetration of drugs through human cadaver skin is reported. Polyethylene glycol 400 was used in various concentrations in the donor and the receptor compartments. It was observed that polyethylene glycol 400 had significant effects on the penetration rates of compounds, both when used in the donor as well as in the receptor solutions. These effects were barrier specific and are related to the alteration of the skin structure and the mass flow of water.

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