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Effect of pilocarpine on insulin secretion in normal and obese hyperglycaemic mice (ob/ob) and in the rat

✍ Scribed by Atkins, Terence W.; Best, Leonard C.; Flatt, Peter R.; Bailey, Clifford J.; Matty, Allen J.

Book ID
122931102
Publisher
Elsevier Science
Year
1975
Tongue
English
Weight
200 KB
Volume
6
Category
Article
ISSN
0306-3623

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Effect of metformin on hepatocyte insuli
Effect of metformin on hepatocyte insulin receptor binding in normal, streptozotocin diabetic and genetically obese diabetic (ob/ob) mice
✍ J. M. Lord; T. W. Atkins; C. J. Bailey πŸ“‚ Article πŸ“… 1983 πŸ› Springer 🌐 English βš– 575 KB

The effect of metformin on hepatocyte insulin receptor binding was examined in normal, streptozotocin diabetic and genetically obese diabetic (ob/ob) mice. In normal mice, chronic administration of metformin (60 mg X kg-1 X day-1 for 50 weeks) increased the number of low affinity receptors by 148%.