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Effect of phosphonic analogues of glutamic acid on glutamate decarboxylase

✍ Scribed by A. M. Lacoste; S. Mansour; A. Cassaigne; E. Neuzil

Publisher
Springer
Year
1985
Tongue
English
Weight
233 KB
Volume
41
Category
Article
ISSN
1420-682X

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A general method based on the sequential reactivities of bis-bromocycloalkenes (3-5) is proposed for the preparation of phosphonocycloalkanes (1a/b-3a/b), representing structural constrained analogues of AP4. For the synthesis of an additional congested AP4 analogue (4), an intramolecular cyclopropa