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Effect of phenylethanolamine N-methyltransferase and dopamine-β-hydroxylase inhibition on epinephrine levels in the brain

✍ Scribed by A.M. Sauter; J.Y. Lew; Y. Baba; M. Goldstein

Book ID: 118937956
Publisher: Elsevier Science
Year: 1977
Tongue: English
Weight: 299 KB
Volume: 21
Category: Article
ISSN: 0024-3205
DOI: 10.1016/0024-3205(77)90310-1

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## Abstract Sixty percent of the dopamine β‐hydroxylase (DBH) (EC 1.14.2.1) activity in rat brain was found to be bound to membrane fractions. The additions of Triton X‐100 solubilized DBH completely and permitted the estimated of the total enzyme activity. In homogenates the DBH could be detected