Effect of Pfaffia iresinoides on the experimental inflammatory process in rats

✍ Scribed by Shirley F. Taniguchi; Ciomar A. Bersani-Amado; Lia S. Sudo; Silvana M. C. Assef; Seizi Oga

• Publisher: John Wiley and Sons
• Year: 1997
• Tongue: English
• Weight: 104 KB
• Volume: 11
• Category: Article
• ISSN: 0951-418X
• DOI: 10.1002/(sici)1099-1573(199712)11:8<568::aid-ptr164>3.0.co;2-3

✦ Synopsis

Antiinflammatory activities of aqueous and saponin extracts and ecdysterone obtained from Pfaffia iresinoides (Sprengel) were studied by using three experimental inflammatory models in rats. The saponin extract (25 and 50 mg/kg, p.o.) reduced the leukocyte migration, particularly of mononuclear cells in the carrageenin-induced pleurisy. It also inhibited the granuloma tissue formation following cotton pellet implantation and the complete Freund's adjuvant-induced arthritis. The aqueous extract, in the same conditions, was effective on both carrageenin-induced pleurisy and complete Freund's adjuvant arthritis. However, it did not alter the granuloma formation. The ecdysterone (5 mg/kg, p.o.), isolated from P. iresinoides, showed no effect on these inflammatory processes.