𝔖 Bobbio Scriptorium
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Effect of peptides of bovine myelin basic protein on dermal fibroblasts

✍ Scribed by Dr. T. M. Chiang; J. N. Whitaker; J. M. Seyer; A. H. Kang

Publisher
John Wiley and Sons
Year
1980
Tongue
English
Weight
413 KB
Volume
5
Category
Article
ISSN
0360-4012

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✦ Synopsis

Abstract

Bovine basic protein (BP) was digested with purified bovine brain cathepsin D to produce well defined BP derived peptides 1–42, 43–88, 43–169, and 89–169. BP and these BP peptides were tested for their effects on cultured human dermal fibroblasts using a concentration range of 0.01–1,000 ng/ml. No effect was found on cellular proliferation, and neither total protein nor collagen synthesis was altered in the presence of these substances. Although preparations of brain which contain a fibroblast‐growth factor also contain BP peptides, these results indicate that the purified BP peptides studied have no detectable biological effect on the growth of human dermal fibroblasts.

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