𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Effect of parathyroid hormone on renal calbindin-D28k

✍ Scribed by Claus Hemmingsen; Michael Staun; Ewa Lewin; Palle K. Nielsen; Klaus Olgaard

Publisher
American Society for Bone and Mineral Research
Year
2009
Tongue
English
Weight
653 KB
Volume
11
Category
Article
ISSN
0884-0431

No coin nor oath required. For personal study only.

✦ Synopsis

The present investigation was conducted to examine the effects of parathyroid hormone (PTH) and parathyroid hormone related peptide (PTHrP) on renal calbindin-D28k in rats. Four groups of studies were performed (1) parathyroidectomy (PTX) or a sham operation followed by infusion of 1,25-dihydroxyvitamin D (1,25[OH],D) or vehicle; (2) infusions of PTH(1-34), PTH(1-84), 1,25(OH),D, or vehicle; (3) infusion of PTHrP(1-34), PTHrP (1-86), PTH(1-34), or vehicle; and (4) injections of calcium or vehicle. PTX reduced renal calbindin-D28k levels even when plasma concentrations of 1,25(OH),D were kept constant by infusion of 1,25(OH),D. Infusions of PTH(1-34), PTH(1-84), and 1,25(OH),D all increased renal calbindin-D28k and plasma calcium, whereas PTHrP( 1-34) and PTHrP( 1-86) increased renal calbindimD28k before an increase of plasma calcium took place. Hypercalcemia induced by the injection of calcium did not affect the levels of renal calbindin-D28k The present data suggest that PTH and PTHrP exert a direct effect on renal calbindin-D28k, which is not mediated by changes of 1,25(OH),D or calcium. (

πŸ“œ SIMILAR VOLUMES

Effect of calbindin-D28K on cyclosporine
Effect of calbindin-D28K on cyclosporine toxicity in cultured renal proximal tubular cells
✍ Ming-Ju Wu; Li-Wen Lai; Yeong-Hau H. Lien πŸ“‚ Article πŸ“… 2004 πŸ› John Wiley and Sons 🌐 English βš– 118 KB

## Abstract Cyclosporine A (CsA) is known to have direct toxicity to renal tubular cells. Its toxicity may be mediated by intracellular calcium because CsA increases intracellular calcium concentration and enhances the activities of calcium‐dependent calpains and caspases. Calbindin‐D~28k~, a cytos

Estrogen responsiveness of renal calbind
Estrogen responsiveness of renal calbindin-D28k gene expression in rat kidney
✍ R.A. Criddle; M.-H. Zheng; I.M. Dick; B. Callus; R.L. Prince πŸ“‚ Article πŸ“… 1997 πŸ› John Wiley and Sons 🌐 English βš– 270 KB

In women, calcium excretion in the urine rises after menopause and falls with estrogen replacement therapy. The amount of calcium lost in the urine following estrogen therapy is less than should occur based on changes in serum calcium and the amount of calcium filtered by the kidney. This suggests t

Effect of parathyroid hormone (hPTH[1-34
Effect of parathyroid hormone (hPTH[1-34]) infusion on serum 1,25-dihydroxyvitamin D and parathyroid hormone in normal women
✍ H. Karimi Kinyamu; J. Christopher Gallagher; Kimberly M. Petranick; Kay L. Rysch πŸ“‚ Article πŸ“… 2009 πŸ› American Society for Bone and Mineral Research 🌐 English βš– 572 KB

Calcium absorption declines with age. Because 1,25-dihydroxyvitamin D (1,25(OH),D) is the major hormone controlling calcium absorption, changes in vitamin D metabolism may account for the malabsorption of aging. Serum levels of 1,25(OH),D have been reported to either decrease or remain unchanged wit