Effect of p-Substitution of Aryl α-D-Mannosides on Inhibiting Mannose-Sensitive Adhesion of Escherichia coli – Syntheses and Testing

✍ Scribed by Thisbe K. Lindhorst; Sven Kötter; Jiří Kubisch; Ulrike Krallmann-Wenzel; Stefan Ehlers; Vladimír Křen

• Publisher: John Wiley and Sons
• Year: 1998
• Tongue: English
• Weight: 388 KB
• Volume: 1998
• Category: Article
• ISSN: 1434-193X
• DOI: 10.1002/(sici)1099-0690(199808)1998:8<1669::aid-ejoc1669>3.0.co;2-q

✦ Synopsis

A series of p-substituted aryl α-D-mannosides was complicated by orthoester formation during the glycosylation reaction. Surprisingly, the inhibitory potency of 10 was lower synthesized and tested with regard to their inhibitory capacity in the hemagglutination of guinea pig erythrocytes than that of p-nitrophenyl α-D-mannoside (1) and this is an important finding for the further design of clustered ligands. by type 1 fimbriated Escherichia coli. Synthesis of the bivalent, phenyl-linked mannoside cluster 10 was