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Effect of P-Glycoprotein on the Rat Intestinal Permeability and Metabolism of the BDDCS Class 1 Drug Verapamil

✍ Scribed by Estudante, Margarida; Maya, Manuela; Morais, José G.; Soveral, Graça; Benet, Leslie Z.

Book ID
121214409
Publisher
American Chemical Society
Year
2013
Tongue
English
Weight
779 KB
Volume
10
Category
Article
ISSN
1543-8384

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✍ Shigeki Tamura; Atsuo Ohike; Rinta Ibuki; Gordon L. Amidon; Shinji Yamashita 📂 Article 📅 2002 🏛 John Wiley and Sons 🌐 English ⚖ 152 KB 👁 1 views

The objective of this study is to investigate the role of P-glycoprotein (P-gp), a membrane ef¯ux pump associated with multidrug resistance (MDR) and a known substrate for tacrolimus, in determining the regional intestinal permeability of tacrolimus in rats. Thus, isolated segments of rat jejunum, i