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Effect of P-glycoprotein-mediated efflux on cerebrospinal fluid concentrations in rhesus monkeys

โœ Scribed by Cuyue Tang; Yuhsin Kuo; Nicole T. Pudvah; Joan D. Ellis; Maria S. Michener; Melissa Egbertson; Samuel L. Graham; Jacquelynn J. Cook; Jerome H. Hochman; Thomayant Prueksaritanont


Book ID
113488845
Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
188 KB
Volume
78
Category
Article
ISSN
0006-2952

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The effect of interferon (IFN)-beta and IFN-gamma on P-glycoprotein (P-gp)-mediated efflux of rhodamin-123(Rho-123), a typical substrate of P-gp, was studied in rat hepatocytes in primary culture. After treatment with IFN-beta, IFN-gamma, or both for 3 days, steady-state levels of Rho-123, incorpora