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Effect of P-Glycoprotein and Breast Cancer Resistance Protein Inhibition on the Pharmacokinetics of Sunitinib in Rats

✍ Scribed by Kunimatsu, S.; Mizuno, T.; Fukudo, M.; Katsura, T.

Book ID
121868131
Publisher
American Society for Pharmacology and Experimental Therapeutics
Year
2013
Tongue
English
Weight
796 KB
Volume
41
Category
Article
ISSN
0090-9556

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## Abstract Sunitinib is an orally active, multitargeted tyrosine kinase inhibitor which has been used for the treatment of metastatic renal cell carcinoma and imatinib‐resistant gastrointestinal stromal tumors. We aimed to investigate the __in vivo__ roles of the ATP‐binding cassette drug efflux t