Effect of orally administered aromatic retinoid on murine Langerhans cells

✍ Scribed by T. Shiohara; M. Kobayashi; H. Narimatsu; M. Nagashima

• Publisher: Springer-Verlag
• Year: 1987
• Tongue: English
• Weight: 851 KB
• Volume: 279
• Category: Article
• ISSN: 0340-3696
• DOI: 10.1007/bf00413258

✦ Synopsis

The effect of orally administered aromatic retinoid (Ro 10-9359) on murine epidermal Langerhans cells (LC) was studied in vivo and in vitro. Daily administration of retinoid caused a transient increase in LC density, as determined by staining for Ia antigens, during the first few days of treatment and thereafter a continuing decrease that reached a maximum at 2 weeks. In addition, the morphology and location in the epidermis had been altered. When the treatment was continued to 4 weeks, the density of LC returned to normal. The Iaantigen-presenting function of epidermal cells to an allo-Ia-reactive cloned T cell line was elevated at aH stages of retinoid treatment examined. This elevation did not correlate with the density of histochemicaHy stainable Ia § LC. These findings suggest that orally administered retinoid profoundly alters the functional capacity of Ia + LC.