Effect of oral therapy with monoisoamyl meso-2,3-dimercaptosuccinate on203Hg retention in rats
✍ Scribed by K. Kostial; M. Blanuša; M. Piasek; M. M. Jones; P. K. Singh
- Book ID
- 112279506
- Publisher
- Springer
- Year
- 1994
- Tongue
- English
- Weight
- 313 KB
- Volume
- 52
- Category
- Article
- ISSN
- 0007-4861
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Monoisoamyl (Mi-ADMS) and mono-n-hexyl (Mn-HDMS) monoesters of meso-2,3-dimercaptosuccinic acid (DMSA) were given orally or parenterally for the mobilization of inorganic mercury in suckling and older rats. Chelators were administered at a dose of 2 x 0.5 mmol kg-1 on two consecutive days 2 weeks af
The effect of nine monoalkyl esters of meso-2,3-dimercaptosuccinic acid (DMSA) on '03Hg retention after a single i.p. dose was evaluated in 6-7 week-old female albino rats. The monoesters were the monomethyl (MMDMS), monoethyl (MEDMS), mono-n-propyl (Mn-PDMS), monoisopropyl (Mi-PDMS), mono-n-butyl (
In this study, efficacy of monoisoamyl meso-2,3-dimercaptosuccinate (Mi-ADMS) was tested to mobilize mercury in the period of gestation in rats. Its action was compared to meso-2,3-dimercaptosuccinic acid (DMSA). Pregnant dams (in second third of gestation) received a single intravenous injection of