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Effect of oral ciprofloxacin on the faecal flora of healthy volunteers

✍ Scribed by Holt, H. A. ;Lewis, D. A. ;White, L. O. ;Bastable, S. Y. ;Reeves, D. S.


Publisher
Springer-Verlag
Year
1986
Weight
365 KB
Volume
5
Category
Article
ISSN
0722-2211

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Sildenafil is the first oral therapeutic agent for the management of male erectile dysfunction. Its oral bioavailability is only 40% due to extensive presystemic elimination, mainly by CYP3A4. This study examined the effect of coadministration of ciprofloxacin or clarithromycin, which inhibit CYP3A4