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Effect of oral acyclovir on pain resolution in herpes zoster: A reanalysis

✍ Scribed by J. Clark Huff; J. L. Drucker; A. Clemmer; O. L. Laskin; J. D. Connor; Y. J. Bryson; Professor H. H. Balfour Jr.

Publisher
John Wiley and Sons
Year
1993
Tongue
English
Weight
356 KB
Volume
41
Category
Article
ISSN
0146-6615

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✦ Synopsis

The most frequent complication of herpes zoster is postherpetic neuralgia, usually defined as chronic pain in the area of the exanthem that persists for at least a month after the skin lesions have healed. Several clinical studies of acyclovir showed a reduction in severity and duration of acute pain, but provided no definitive data for chronic pain. In order to determine if acyclovir therapy could reduce chronic pain, we reanalyzed data from the largest U.S. placebo-controlled treatment trial of 187 immunocompetent persons with herpes zoster. By considering pain as a continuum, we found that the median duration of pain in acyclovir recipients was 20 days vs. 62 days for their placebo counterparts (P = 0.02). Thus, acyclovir has been shown to reduce chronic zoster-associated pain. We also noted that the absence of pain at the onset of cutaneous herpes zoster did not preclude its later development. Q 1993 Wiley-Liss, Inc.

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