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Effect of opicapone multiple-dose regimens on levodopa pharmacokinetics, motor response, and erythrocyte-COMT activity in Parkinson's patients co-administered with levodopa/dopa-decarboxylase inhibitor

✍ Scribed by Ferreira, J.J.; Rocha, J.-F.; Falcão, A.; Pinto, R.; Nunes, T.; Soares-da-Silva, P.


Book ID
123123697
Publisher
Elsevier Science
Year
2013
Tongue
English
Weight
63 KB
Volume
333
Category
Article
ISSN
0022-510X

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Effect of entacapone, a COMT inhibitor,
✍ V. V. Myllylä; K. A. Sotaniemi; A. Illi; K. Suominen; T. Keränen 📂 Article 📅 1993 🏛 Springer 🌐 English ⚖ 563 KB

In an open, randomised, cross-over study we investigated the effect of a single 200 mg oral dose of entacapone, a novel catechol-O-methyltransferase (COMT) inhibitor, on the pharmacokinetics and metabolism of levodopa/carbidopa, and on the cardiovascular responses (blood pressure and pulse rate vari