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Effect of omeprazole treatment on diazepam plasma levels in slow versus normal rapid metabolizers of omeprazole

✍ Scribed by Andersson, Tommy; Cederberg, Christer; Edvardsson, Gunilla; Heggelund, Asger; Lundborg, Per

Book ID
109844735
Publisher
Nature Publishing Group
Year
1990
Tongue
English
Weight
515 KB
Volume
47
Category
Article
ISSN
0009-9236

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In a randomised double-blind crossover study, seven healthy males were concomitantly given metoprolol 100 mg o.d. as a controlled release formulation, and omeprazole 40 mg o.d. or placebo, for 8 days. Plasma levels of the R- and S-enantiomers of metoprolol were determined on the 8th day of each trea