Effect of North Bicyclo[3.1.0]hexane 2′-Deoxy-pseudosugars on RNA Interference: A Novel Class of siRNA Modification

Inside Cover: Effect of North Bicyclo[3.

Inside Cover: Effect of North Bicyclo[3.1.0]hexane 2′-Deoxy-pseudosugars on RNA Interference: A Novel Class of siRNA Modification (ChemBioChem 7/2011)

✍ Dr. Montserrat Terrazas; Dr. Sandra M. Ocampo; Dr. José Carlos Perales; Prof. Dr 📂 Article 📅 2011 🏛 John Wiley and Sons 🌐 English ⚖ 492 KB

The inside cover picture shows how siRNAs modified with North bicyclo-[3.1.0]hexane 2'-deoxy-pseudosugars are able to activate the RNA interference machinery. The paper confirms that the North conformation is critical for RNAi activity. For further details, see the Full Paper by R. Eritja et al. on