Effect of nonionic surfactants on the transport of testosterone across a cellulose acetate membrane

✍ Scribed by P. M. Short; E. T. Abbs; C. T. Rhodes

• Publisher: John Wiley and Sons
• Year: 1970
• Tongue: English
• Weight: 406 KB
• Volume: 59
• Category: Article
• ISSN: 0022-3549
• DOI: 10.1002/jps.2600590716

✦ Synopsis

Solubilization of testosterone by a series of three alkylpolyoxyethylene surfactants at 37" has been examined as a function of surfactant concentration. The effect of these surfactants has also been investigated upon the diffusion of testosterone through cellulose acetate membranes. Diffusion coefficients were calculated using a method that allows the measurements to be completed in a very short time. Possible mechanisms by which surfactants may affect drug transport are discussed. In all cases examined, the surfactants reduced the diffusion coefficient of testosterone.

Keyphrases

Testosterone transport-cellulose membrane 0 Surfactants effect-testosterone transport, cellulose membrane 0 Solubilization, testosterone-surfactants 0 Diffusion coefficienttestosterone ACKNOWLEDGMENTS AND ADDRESSES