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Effect of non-complementary nucleotides on the rate of helix formation: Kinetics of formation of poly (I)·poly (C,I) and poly (I)·poly (C,U) complexes

✍ Scribed by Neville R. Kallenbach; Stanley D. Drost

Publisher
Wiley (John Wiley & Sons)
Year
1972
Tongue
English
Weight
386 KB
Volume
11
Category
Article
ISSN
0006-3525

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✦ Synopsis

Abstract

Apparent second‐order rate constants for complex formation between poly (I) and poly (C) and copolymers of C containing non‐complementary I or U residues have been determined spectrophotometrically. The rate constants decrease as the concentration of either I or U in the C strands increases–the effect seems insensitive to the species of residue involved, when differences in the thermal stabilities of the poly (I) poly (C,I) and poly (I). poly (C,U) complexes are taken into account. These results suggest that low concentrations of relatively stable defects can alter the apparent kinetic “complexity” of polynucleotides as determined by hybridization methods (C~0~t analysis).

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