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Effect of nitrofurantoin on meiosis of the male mouse

✍ Scribed by Christa Fonatsch

Publisher: Springer
Year: 1977
Tongue: English
Weight: 373 KB
Volume: 39
Category: Article
ISSN: 0340-6717
DOI: 10.1007/bf00295430

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✦ Synopsis

The effects of nitrofurantoin [N-(5-nitro-2-furfurylidine)-1-amino-hydantoin] on chromosomes of primary and secondary spermatocytes of mice were studied. No mutagenic activity was detectable after application of either 8 mg/kg or 40 mg/kg nitrofurantoin. An increase in the univalent rates and a decrease in the chiasma frequencies was observed in treated animals. The probable origins of these effects are discussed.

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