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Effect of Ni(II) on inflammatory gene expression in THP1 monocytic cells

โœ Scribed by Li, Lei; Drury, Jeanie L.; Zhang, Hai; Sun, Jianxun; DiJulio, Dennis; Chung, Whasun O.; Wataha, John C.

Book ID
118762335
Publisher
John Wiley and Sons
Year
2012
Tongue
English
Weight
437 KB
Volume
101A
Category
Article
ISSN
1549-3296

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## Abstract The transcription factor NFฮบB plays a key role in the tissue inflammatory response. Metal ions released into tissues from biomaterials (e.g., Au, Pd, Ni, Hg) are known to alter the binding of NFฮบB proteins to DNA, thereby modulating the effect of NFฮบB on gene activation and, ultimately,