Effect of nifedipine on the recovery of cerebral high-energy phosphates after cardiac arrest and resuscitation in the rat

✍ Scribed by HG Garrison; AR Hansen; GW Palladino; DC Fillipo; HJ Proctor

• Publisher: Elsevier Science
• Year: 1985
• Tongue: English
• Weight: 149 KB
• Volume: 14
• Category: Article
• ISSN: 1097-6760
• DOI: 10.1016/s0196-0644(85)80388-7

✦ Synopsis

tocopherol acetate (500 mg), and compression in a hyperbaric oxygen chamber to 2 atmospheres absolute. Six control dogs were not treated. All dogs were transferred to an ICU. Critical care management and neurologic scoring was performed for up to 7 days by blinded observers. Neurologic scoring was done every hour using a positive scoring scale. All dogs at the time of death underwent autopsies for both gross and microscopic analysis. Mean survival time for the control dogs was 6.5 h + 3.7, and for the treated dogs it was 73.9 h + 65.4 (P = .001). The highest total neurologic score achieved also was statistically significant (P = .021). Three of the treatment dogs awakened from a comatose state, while none of the control dogs did. Two of the treated dogs did well neurologically. We conclude that the treatment regimen improved survival time and appeared to have a beneficial neurologic effect.