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Effect of nicardipine on haemodynamic response to stress in hypertension

โœ Scribed by T. Takabatake; Y. Yamamoto; S. Nakamura; N. Hashimoto; S. Satoh; Y. Yamada; K. Kobayashi

Publisher
Springer
Year
1992
Tongue
English
Weight
518 KB
Volume
42
Category
Article
ISSN
0031-6970

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โœฆ Synopsis

The effects of the calcium antagonist nicardipine on the pressor response to mental arithmetic, cold pressor and exercise tests have been studied in fifteen patients with established mild to moderate essential hypertension. Nicardipine 20 mg p.o. showed a hypotensive effect within 60 min, associated with a fall in total peripheral resistance and an increase in heart rate. As the pressor response to each stress was not affected by nicardipine, the peak blood pressure reached during each stress was lower. Nicardipine lowers blood pressure at rest as a result of arteriolar dilatation, associated with reflex tachycardia. The pressor responsiveness to various stresses was not affected by nicardipine.

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