Effect of neutron-gamma radiation on dopamine and serotonin metabolism in the rat brain: A regional analysis

✍ Scribed by Olivier Foulon; Frédéric Lalouette; Fabrice Lambert; Serge Martin; Marc Fatôme; Christine Martin

• Publisher: John Wiley and Sons
• Year: 1999
• Tongue: English
• Weight: 41 KB
• Volume: 55
• Category: Article
• ISSN: 0360-4012
• DOI: 10.1002/(sici)1097-4547(19990315)55:6<770::aid-jnr11>3.0.co;2-a

✦ Synopsis

The concentrations of dopamine (DA) and its metabolites and the levels of 5-hydroxyindoleacetic acid (5-HIAA), the metabolite of serotonin, were determined in discrete cerebral areas of rats 3 hr after (neutron-gamma) irradiation at 4 and 7 Gy. After the 7 Gy irradiation, no significant effect was observed. After the 4 Gy exposure, the most marked difference between irradiated and control rats was in the levels of DA and its metabolites in the striatum. We observed a decrease of DA, HVA, and DOPAC levels in the striatum and an opposite pattern in the substantia nigra. Whatever the brain area observed, an increase of 5-HIAA levels was noted.