Effect of nerve growth factor and its transforming tyrosine kinase protein and low-affinity nerve growth factor receptors on apoptosis of notochordal cells
โ Scribed by Suhl, Kyung-Hwan; Park, Jong-Beom; Park, Eun-Young; Rhee, Seung-Koo
- Book ID
- 111865497
- Publisher
- Springer
- Year
- 2012
- Tongue
- English
- Weight
- 422 KB
- Volume
- 36
- Category
- Article
- ISSN
- 0341-2695
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In our preceding report, we have shown that nerve growth factor (NGF) and its low-affinity receptor (p75 NTR ) are expressed in C2C12 myoblasts and downregulated during myogenic differentiation. Furthermore, NGF affects myogenic differentiation and cell growth via p75 NTR and downregulation of p75 N
Mutant PC12 cell clones (PC84 cells) were obtained by transfection with nerve growth factor (NGF) cDNA. These cells secreted active NGF, extended short processes, and proliferated faster than the parental PC12 cells. These features are of great interest because the parental PC12 cells cease prolifer