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Effect of naringin pretreatment on bioavailability of verapamil in rabbits

โœ Scribed by Cheul-Ho Yeum; Jun-Shik Choi

Book ID
105672900
Publisher
Springer
Year
2006
Tongue
English
Weight
528 KB
Volume
29
Category
Article
ISSN
0253-6269

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It was reported that verapamil is metabolized via hepatic microsomal cytochrome P450 (CYP) 3A4 and that naringin (a component of grapefruit juice) inhibits CYP3A4 in humans. Hence, after oral administration of verapamil, the total area under the plasma concentration-time curve from time zero to time

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