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Effect of naloxone on the behaviour of rats exposed to a novel environment

✍ Scribed by R. John Rodgers; Robert M. J. Deacon

Publisher
Springer
Year
1979
Tongue
English
Weight
250 KB
Volume
65
Category
Article
ISSN
0033-3158

No coin nor oath required. For personal study only.

✦ Synopsis

it has recentty been suggested that endogenous opiates may play a general role in stress responding. To test this hypothesis, naloxone by. drochloride (0.5-4.0 mg/kg SC) was administered to rats exposed to an open field situation. Naloxone treatment produced a decrease in locomotor activity and rearing, and an increase in defaecation. A simple dose-response relationship was not observed, with the most potent effects exerted by the I mg/kg dose. Nevertheless, these results indicate that naloxone increases emotionatity in the rat and suggest that opioid peptides may be released under conditions of nonpainful stress.

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