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Effect of naloxone on luteinizing hormone secretion in eating disorders: A pilot study

โœ Scribed by Baraban, Jay M. ;Walsh, B. Timothy ;Gladis, Madeline ;Roose, Steven P. ;Dyrenfurth, Inge ;Linkie, Daniel ;Wiele, Raymond Vande

Publisher
Wiley (John Wiley & Sons)
Year
1986
Tongue
English
Weight
372 KB
Volume
5
Category
Article
ISSN
0276-3478

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โœฆ Synopsis

Previous studies have suggested that increased activity in endogenous opiate systems can lead to suppression of LH secretion in certain normal and pathological states. Increased food intake has also been linked to increased endogenous opiate activity. We hypothesized that in some women with the syndrome of bulimia there is an increase in endogenous opiate system activity which contributes both to a suppression of LH secretion and to an increased drive to eat. We tested the endocrine aspect of this hypothesis by determining the effect of naloxone on LH secretion in nine amenorrheic or oligomenorrheic women with bulimia. Naloxone failed to increase LH in five underweight women with bulimia and anorexia nervosa. There was a slight increase in LH secretion during naloxone infusion in two of four women of normal weight with bulimia.

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