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Effect of N-cadherin misexpression by the mammary epithelium in mice

โœ Scribed by Karen A. Knudsen; Christa Sauer; Keith R. Johnson; Margaret J. Wheelock

Publisher
John Wiley and Sons
Year
2005
Tongue
English
Weight
333 KB
Volume
95
Category
Article
ISSN
0730-2312

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โœฆ Synopsis

Abstract

Nโ€cadherin is not typically expressed by epithelial cells. However, it is detected in breast cancers and increases tumor cell migration and invasion in vitro. To explore its misexpression, we generated transgenic mice with Nโ€cadherin in the mammary epithelium. Mammary glands appeared normal and no tumors arose spontaneously. To investigate Nโ€cadherin misexpression in mammary tumors, neu was overexpressed through breeding. Tumors developed in +/neu and Nโ€cadherin/neu mice, although few tumors in bitransgenic mice expressed Nโ€cadherin, and they did not differ from Nโ€cadherinโ€negative tumors. ยฉ 2005 Wileyโ€Liss, Inc.

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