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Effect of N 9 -Methylation and Bridge Atom Variation on the Activity of 5-Substituted 2,4-Diaminopyrrolo[2,3- d ]pyrimidines against Dihydrofolate Reductases from Pneumocystis carinii and Toxoplasma gondii 1a,b

✍ Scribed by Gangjee, Aleem; Mavandadi, Farahnaz; Queener, Sherry F.

Book ID
126004673
Publisher
American Chemical Society
Year
1997
Tongue
English
Weight
164 KB
Volume
40
Category
Article
ISSN
0022-2623

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✍ Andre Rosowsky; Hongning Fu; Sherry F. Queener 📂 Article 📅 2000 🏛 Journal of Heterocyclic Chemistry 🌐 English ⚖ 560 KB

## Abstract The synthesis of four previously undescribed 2,4‐diaminopyrido[2,3‐__d__]pyrimidines (**3,4**) and 2,4‐diaminoquinazolines (**5,6**) with a bulky tricyclic aromatic group at the 6‐position is described. Condensation of dibenz[__b,f__]azepine with 2,4‐diamino‐6‐bromomethylpyrido[2,3‐__d_