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Effect of mutations in HNF-1α and HNF-1β on the transcriptional regulation of human sucrase–isomaltase in Caco-2 cells

✍ Scribed by Ning Gu; Naoko Suzuki; Jun Takeda; Tetsuya Adachi; Gozoh Tsujimoto; Norihiko Aoki; Akihiko Ishihara; Kinsuke Tsuda; Koichiro Yasuda


Book ID
116289384
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
372 KB
Volume
325
Category
Article
ISSN
0006-291X

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Human renal cell carcinoma (RCC) is a common malignant disease of the kidney characterized by dedifferentiation of renal epithelial cells. Our previous experiments showed that most RCCs have a loss of function of the tissue-specific transcription factor hepatocyte nuclear factor (HNF) 1α. Detailed a